Projects

Classification of the dissertation projects: PhD student (Supervisor)


 

Publications of the GRK1172 PhD students, listed after their
supervisors and institutions

Faculty of medicine



G. Geisslinger, E. Niederberger
Möser C, Kynast K, Baatz K, Daume T, Schmidtko A, Tegeder I, Geisslinger G and Niederberger E.
Impaired inflammatory nociception in mice lacking I-κB Kinase epsilon, zur Publikation eingereicht.

T. Klingebiel, U. Köhl
Huenecke S, Zimmermann SY, Kloess S, Esser R, Brinkmann A, Tramsen L, Koenig M, Erben S, Seidl C, Tonn T, Eggert A, Schramm A, Bader P, Klingebiel T, Lehrnbecher T, Passweg JR, Soerensen J, Schwabe D, Koehl U.
IL-2-driven regulation of NK cell receptors with regard to the distribution of CD16+ and CD16- subpopulations and in vivo influence after haploidentical NK cell infusion. J Immunother. 2010 Feb-Mar;33(2):200-10.

Huenecke S, Behl M, Fadler C, Zimmermann SY, Bochennek K, Tramsen L, Esser R, Klarmann D, Kamper M, Sattler A, Kvon Laer D, Klingebiel T, Lehrnbecher T, Koehl U.
Age-matched lymphocyte subpopulation reference values in childhood and adolescence: application of exponential regression analysis. Eur J Haematol 80:532-9, 2008.

Hollatz G, Grez M, Mastaglio S, Quaritsch R, Huenecke S, Ciceri F, Bonini C, Esser R, Klingebiel T, Kreuter J, Koehl U.
T cells for suicide gene therapy: Activation, functionality and clinical relevance. J Immunol Methods 29;331(1-2):69-81, 2008.

Klöss S, Bochennek K, Huenecke S, Zimmermann SY, Kuçi S, Müller T, Wels WS, Klingebiel T, Esser R, Koehl U.
A novel five-colour flow cytometric assay to determine NK cell cytotoxicity against neuroblastoma and other adherent tumour cells. J Immunol Methods 325:140-147, 2007.

Koehl U, Dirkwinkel E, Koenig M, Erben S, Soerensen J, Bader P, Doerr HW, Preiser W, Weissinger E, Klingebiel T, Martin H, Lehrnbecher T.
Reconstitution of Cytomegalovirus Specific T Cells after Pediatric Allogeneic Stem Cell Transplantation: Results from a Pilot Study Using a Multi-Allele CMV Tetramer Group. Klinische Pädiatrie 220(6):348-52, 2008.

Koenig M, Huenecke S, Salzmann E, Esser R, Quaritsch R, Steinhilber D, Radeke HH, Martin H, Bader P, Klingebiel T, Schwabe D, Schneider G, Lehrnbecher T, Orth A, Koehl U.
Multivariate analyses of immune reconstitution in children following allogeneic stem cell transplantation: Risk-estimation based on age-matched leukocyte subpopulations, im Druck.

Kuçi S, Kuçi Z, Kreyenberg H, Deak E, Pütsch K, Huenecke S, Amara C, Koller S, Rettinger E, Grez M, Koehl U, Latifi-Pupovci H, Henschler R, Tonn T, von Laer D, Klingebiel T, Bader P.
CD271 antigen defines a subset of multipotent stromal cells with immunosuppressive and lymphohematopoietic engraftment-promoting properties. Haematologica. 2010 Apr;95(4):651-9. Epub 2010 Feb 23.



J. Pfeilschifter/S. Frank/H. Mühl
Goren I, Kämpfer H, Müller E, Schiefelbein D, Pfeilschifter J, Frank S.
Oncostatin M expression is functionally connected to neutrophils in the early inflammatory phase of skin repair: implications for normal and diabetes-impaired healing. J Invest Dermatol 126, 628-637, 2006.

Goren I, Müller E, Schiefelbein D, Christen U, Pfeilschifter J, Mühl H, Frank S.
Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages. J Invest Dermatol 127, 2259-2267, 2007.

Schiefelbein D, Goren I, Fisslthaler B, Schmidt H, Geisslinger G, Pfeilschifter J, Frank S.
Biphasic regulation of HMG CoA reductase expression and activity during wound healing and ist functional role in the control of keratinocyte angiogenic and proliferative responses. J Biol Chem 283, 15479-15490, 2008.

Schiefelbein D, Seitz O, Goren I, Dissmann J, Schmidt H, Bachmann M, Sader R, Geisslinger G, Pfeilschifter J, Frank S.
Keratinocyte-derived vascular endothelial growth factor biosynthesis represents a pleiotropic side effect of peroxisome proliferator-activated receptor-gamma agonist troglitazone but not rosiglitazone and involves activation of p38 mitogen-activated protein kinase: implications for diabetes-impaired skin repair. Mol Pharmacol 74, 952-963, 2008.

Goren I, Müller E, Schiefelbein D, Gutwein P, Seitz O, Pfeilschifter J, Frank S.
Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice. J Invest Dermatol 129, 752-764, 2009.

Ziesche E, Bachmann M, Kleinert H, Pfeilschifter J, Mühl H.
The IL-22/STAT3 pathway potentiates expression of iNOS in human carcinoma cells. J Biol Chem. 282:16006, 2007.

Ziesché E, Scheiermann P, Sadik CD, Hofstetter C, Zwissler B, Pfeilschifter J, Mühl H.
Dexamethasone suppresses IL-22 production associated with bacterial infection in vitro and in vivo, Clin Exp Immunol. 157:370-376, 2009.

Bingold TM, Ziesché E, Scheller B, Sadik CD, Franck K, Just L, Sartorius S, Wahrmann M, Wissing H, Zwissler B, Pfeilschifter J, Mühl H. Interleukin-22 Detected in Patients with Abdominal Sepsis, Shock (in press), 2010

P. Gutwein
Gutwein P, Schramme A, Abdel-Bakky MS, Doberstein K, Hauser IA, Ludwig A, Altevogt P, Gauer S, Hillmann A, Weide T, Jespersen C, Eberhardt W, Pfeilschifter J.
ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases. J Biomed Sci. 2010 Jan 13;17:3.

Lee SB, Doberstein K, Schramme A, Dummer R, Abdel-Bakky MS, Keller S, Altevogt P, Oh ST, Reichrath J, Oxmann D, Pfeilschifter J, Mihic-Probst D, Gutwein P.
ADAM10 is upregulated in melanoma metastasis compared with primary melanoma.
J Invest Dermatol. 2010 Mar;130(3):763-73. Epub 2009 Oct 29


H. Radeke
Richter C, Herrero San Juan M, Will J, Brandes RP, Kalinke U, Akira S, Pfeilschifter JM, Hultqvist M, Holmdahl R, Radeke HH.
Ncf1 provides a ROS-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells, Journal of Immunology, 2009. J. Immunol. 182(7):4183-91.

Giegold O, Ludwig RJ, Hardt K, Will J, Schön MP, Pfeilschifter JM, Boehncke WH and Radeke HH.
Computer-aided analysis of cell interactions under dynamic flow conditions. Experimental Dermatology, 18:238-245, 2009.

T. Tonn, E. Seifried
Roth SD, Sapp M, Streeck RE, Selinka HC.
Characterization of neutralizing epitopes within the major capsid protein of human papillomavirus type 33. Virology Journal 3:83, 2006.

Schüttrumpf J, Milanov P, Roth S, Seifried E, Tonn T.
[Non-viral gene transfer results in therapeutic factor IX levels in haemophilia B mice.] Hamostaseologie. Oct;28 Suppl 1:S92-5, 2008.

Hermann FG, Martinius H, Egelhofer M, Zahn R, Tonn T, Roth SD, Schult-Dietrich P, Dietrich U, Alexandrov A, Baum C, von Laer D.
Protein scaffold and expression level determine antiviral activity of membrane-anchored antiviral peptides. Hum. Gene Ther. Epub, 2008 Dec 29.

Gleixner E, Abriss D, Adryan B, Kraemer M, Gerlach F, Schuh R, Burmester T, Hankeln T.
Oxygen-induced changes in hemoglobin expression in Drosophila. FEBS Journal, 275(20):5108-16, 2008.



Fachbereich 14: Biochemie, Chemie und Pharmazie


J. Engels
Wittel G, Bats JW, Engels JW.
”3´,5´-Bis(tert-butyldimethylsilyl)-5-iodo-2´-deoxy-cytidine”, Acta Cryst., E63m o2657-o2659, 2007.

Wittel G, Gu P, Engels J W.
“Synthesis and Activity of C-Analogues for Immune Stimulating CpG-Oligodeoxynucleotides”, Collection Symposium Series, 7: 493-494, 2005.

Rehm S, Han S, Hassani I, Sokocevic A, Jonker HR, Engels JW, Schwalbe H.
The high resolution NMR structure of parvulustat (Z-2685) from Streptomyces parvulus FH-1641: comparison with tendamistat from Streptomyces tendae 4158; ChemBioChem,10 (1):119-27, 2009.


D. Steinhilber
Lindner SC, Köhl U, Maier TJ, Steinhilber D, Sorg B.
TLR2 ligands augment cPLA2α activity and lead to enhanced leukotriene release in human monocytes. J. Leuk. Biol., in Revision.



Georg-Speyer-Haus


B. Groner
Borghouts C, Weiss A.
Production and purification of monomeric recombinant peptides for efficient intracellular uptake
and target inhibition. In: Peptides as Drugs - Discovery and Development (Ed. Groner, B.), Wiley-VCH, 2009.


M. Grez
Wichmann C, Becker Y, Grez M.
Intracellular expression of peptides. Buchbeitrag in: Groner (Ed.): Peptides as Drugs - Discovery and Development

Stein S, Ott MG, Schultze-Strasser S, Jauch A, Burwinkel B, Kinner A, Schmidt M, Krämer A, Martin H, Glimm H, Koehl U, Preiss C, Göhring G, Schwarzwaelder K, Hofmann WK, Bleuel K, Tchatchou S, Yang R, Reinecke P, Kühlcke K, Schlegelberger B, Thrasher AJ, Hoelzer D, Seger R, von Kalle C, Grez M.
Genomic Instability and Myelodysplasia with Monosomy 7 caused by EVI1 Activation after Gene Therapy for Chronic Granulomatous Disease, Nat Med. 2010, 16:198-204.

Vogler I, Newrzela S, Hartmann S., Schneider N, von Laer D, Koehl U, Grez M.
Adoptive T cell Immunotherapy with an Improved Bicistronic CD20 Vector for Efficient Purification and in vivo Depletion of Gene-modified T Cells. Mol Ther. 2010, in press.

Wichmann C., Becker Y., Chen-Wichmann L., Vogel V., Vojtkova A., Herglotz J., Moore S., Koch J., Lausen J., Mäntele W., Gohlke H., Grez M.
Dimer-tetramer transition controls AML1/ETO leukemogenic activity.
Blood, 2010, in press.

Isabel Vogler, Sebastian Newrzela, Sylvia Hartmann, Nadine Schneider, Dorothee von Laer, Ulrike Koehl and Manuel Grez
An Improved Bicistronic CD20/tCD34 Vector for Efficient Purification and In Vivo Depletion of Gene-Modified T Cells for Adoptive Immunotherapy.
Molecular Therapy (2010); doi:10.1038/mt.2010.83


D. von Laer/U. Dietrich
Van Lunzen, J, Glaunsinger T, Stahmer I, von Baehr V, Baum C, Brendel C, Schilz A, Kuehlcke K, Naundorf S, Martinius H, Hermann F, Giroglou T, Newrzela S, Choi I, Brauer F, Brandenburg G, Alexandrov A, von Laer D.
Transfer of autologous gene-modified T lymphocytes in HIV-infected patients with severe immunodeficiency. Mol. Ther. 15:1024-1033, 2007.

Kimpel J*, Braun SE*, Qiu G, Wong FE, Conolle M, Schmitz JE, Humeau M, Dropulic B, Rossi JJ, Berger A, von Laer D*, Johnson RP*. Survival of the Fittest: Selection of vector-transduced cells during HIV-1 replication, zur Publikation eingereicht. *equal contribution.


W. Wels/M. Zörnig
Giesübel U, Dälken B, Mahmud H, Wels WS.
Cell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast Pichia pastoris. Biochem. J. 394: 563-573, 2006.

Mahmud H, Dälken B, Wels WS.
Induction of programmed cell death in ErbB2/HER2-expressing cancer cells by targeted delivery of apoptosis inducing factor AIF. Mol. Cancer Ther., Mol Cancer Ther. 2009 Jun;8(6):1526-35. Epub 2009 Jun 9.

Tavri S, Jha P, Meier R, Henning TD, Müller T, Hostetter D, Knopp C, Johannson M, Reinhart V, Boddington S, Sista A, Wels WS, Daldrup-Link HE.
Optical imaging of cellular immunotherapy against prostate cancer. Mol. Imaging 2009, im Druck.

Jha P, Reinhart V, Knopp C, Li S, Wels WS, Daldrup-Link H.
NK-cell tracking using non-invasive imaging modalities. in: Natural killer cells, Eds.: Lotze M, Thomson A. Elsevier, im Druck.

Sloots A, Mastini C, Rohrbach F, Weth R, Curcio C, Burkhardt U, Jäger E, Forni G, Cavallo F, Wels WS.
DNA vaccines targeting tumor antigens to B7 molecules on APCs induce protective anti-tumor immunity and delay onset of HER2/Neu-driven mammary carcinoma. Clin. Cancer Res. 14: 6933-6943, 2008.

Rabenhorst et al.:
“Overexpression of the Far Upstream Element (FUSE) Binding Protein in Hepatocellular Carcinoma (HCC) is required for Tumor Growth”, zur Publikation akzeptiert in Hepatology.



Paul-Ehrlich-Institut


K. Cichutek/C. Buchholz/M. Schweizer
Funke S, Schneider IC, Glaser S, Mühlebach MD, Moritz T, Cattaneo R, Cichutek K, Buchholz CJ.
Pseudotyping lentiviral vectors with the wildtype measles virus glycoproteins improves titer and selectivity. Gene Therapy, Epub, 12 February 2009.

Funke S, Maisner A, Mühlebach MD, Koehl U, Grez M, Cattaneo R, Cichutek K, Buchholz CJ.
Targeted cell entry of lentiviral vectors. Molecular Therapy, Vol. 16 (8): 1427-1436, 2008.

Buchholz CJ, Duerner LJ, Funke S, Schneider IC.
Retroviral Display and High Throughput Screening. Combinatorial Chemistry & High Throughput Screening, Vol. 11 (2): 99-110, 2008.

Europäische Patentanmeldung am 27.09.2006 (06020257.9; Veröffentlichungsnr. 1975239) und PCT-Anmeldung am 26.09.2007 (PCT/EP2007/008384; Veröffentlichungsnr. WO 2008/037458 A3) mit dem Titel „Pseudotyping of retroviral vectors, methods for production and use thereof for targeted gene transfer and high-throughput screening” Erfinder: Buchholz CJ, Funke S, Cichutek K, Cattaneo R.

Mühlebach MD, Schüle S, Kaiser JK, Kloke B-P, Cichutek K, Schweizer M
Impact of viral accessory proteins of SIVsmmPBj on early steps of infection of quiescent cells. Wolfrum N, Virology 364: 330-341, 2007.


Barbara Schnierle
Kremer M, Klemke CD, Schnierle BS.
Rapamycin delays tumor growth of cutaneous T-cell lymphomas, in Vorbereitung.

Frei G, Kremer M, Hanschmann K, Krause S, Albeck M, Sredni B, Schnierle BS.
Antitumour effects in mycosis fungoides of the immunomodulatory, tellurium-based compound, AS101. British Journal of Dermatology 158: 578-586, 2008.

Kremer M, Suezer Y, Martinez-Fernandez Y, Munk C, Sutter G, Schnierle BS.
Vaccinia virus replication is not affected by APOBEC3 family members. Virol. J. 3: 86, 2006.

Kremer M, Bittner A, Schnierle BS.
Human APOBEC3G incorporation into murine leukemia virus particles. Virology 337: 175-182, 2005.

Kremer M, Schnierle BS.
HIV-1 Vif: HIV’s weapon against the cellular defense factor APOBEC3G. Curr. HIV. Res. 3: 339-344, 2005.

Christel Kamp, Timo Wolf, Ignacio G Bravo, Benjamin Kraus, Birgit Krause, Britta Neumann, Gudrun Winskowsky, Alexander Thielen, Albrecht Werner and Barbara S Schnierle
Decreased HIV diversity after allogeneic stem cell transplantation of an HIV-1 infected patient: a case report
Virology Journal 2010, 7:55doi:10.1186/1743-422X-7-55